北京生物医学工程2013，Vol.32Issue(3)：291-295,5.DOI:10.3969/j.issn.1002-3208.2013.03.14
晚期糖基化终产物受体基因多态性与肥胖的关联研究
An association study between the gene polymorphisms of receptor for advanced glycation end-products and obesity
摘要
Abstract
Objective To evaluate the association between three single nucleotide polymorphisms (SNPs) of receptor for advanced glycation end-products (RAGE) gene and obesity in Han Chinese population.Methods Totally 2,731 adult subjects aged 18-62 were recruited from a rural population of 14,469 subjects in Jiangsu province by an epidemiological stratification sampling approach.Linkage disequilibrium (LD) analysis was applied and three tagging SNPs (tagSNPs) of RAGE gene,rs1800624,rs204993,rs184003 were selected for genotyping and analyzing for the association with obesity.Results SNP rs1800624 had significant association with obesity and OR (95％ CI) were 0.807 (0.669-0.974) and 0.762 (0.617-0.939)in additive model and dominant models after the adjustment for confounding factors such as age,sex,physical activity index and income.Further stratification analysis by sex indicated that individuals carrying T allele (AT+TT) of SNP rs1800624 had higher susceptibility to obesity than CC genotype in male.No significant difference of BMI was found between genotype variations of rs1800624,rs204993 and rs184003.Conclusions Our result suggests that SNP rs1800624 of RAGE gene is associated with increased risk of obesity in Han Chinese men,and further replication study would be warranted.关键词
晚期糖基化终产物受体/肥胖/BMI/关联研究Key words
receptor for advanced glycation endproducts/obesity/body mass index/association study分类
医药卫生引用本文复制引用
黄福华,王滢,赵祥海,陈金凤,王海茹,杨松,赵彦平,陈燕春,李莉..晚期糖基化终产物受体基因多态性与肥胖的关联研究[J].北京生物医学工程,2013,32(3):291-295,5.基金项目
江苏省自然科学基金项目(BK2011776)、南京市医学科技发展项目(KF2009150)、江苏高校优势学科建设工程项目资助 （BK2011776）
