北京中医药大学学报2013，Vol.36Issue(5)：317-321,后插1,6.DOI:10.3969/j.issn.1006-2157.2013.05.008
基于数字化定量的高尿酸血症鹌鹑模型“四诊”证候研究
Study on syndromes in four examinations based on digital quantification in quail model of hyperuricemia
摘要
Abstract
Objective To quantify objectively the indexes of uric acid (UA),excrement,urine and tongue manifestation in quail model of hyperuricemia,investigate the types of TCM syndromes,and provide reference for reviewing quail model of TCM syndromes.Methods The quail model of hyperuricemia was induced by high purine diet.The changes of UA level,characters of excrement and urine and tongue manifestation were observed dynamically,which was then given disproof with Juju (Herbacichorii) with the actions of fortifying spleen and draining dampness.The types of TCM syndromes were discussed in the quail model from two angles including four examinations and inferring syndromes by medicinal.Results The results of inquiry,listening-smelling and inspection showed that the net weight of excrement and urine trended to increase and dilute with strong smell in model group on the 17th day and 30th day.The color of tongue body is mainly red in normal group and pale in model group.The proportion of tongue redness r and red area decreased significantly on the 22nd day and 32nd day,and UA level increased significantly on the 14th day and 21st day in model group(P ＜ 0.05).The net weight and dry weight of excrement and urine (P ＜ 0.05),and proportion of tongue redness r and red area increased significantly in Juju group (P ＜ 0.05) compared with model group.The level of UA decreased significantly in Juju group on the 21 st day (P ＜ 0.05).Conclusion The quail model of hyperuricemia can be successfully induced by high purine diet.The quantified study on indexes of four examinations and inferring syndromes by medicinal indicates that part pathological changes of quail model is similar to spleen deficiency and phlegm-dampness syndrome induced by disorder diet.关键词
鹌鹑/证候/高尿酸血症/脾虚痰湿/四诊Key words
quails/syndromes/hyperuricemia/spleen deficiency and phlegm-dampness syndrome/four examinations分类
医药卫生引用本文复制引用
林志健,张冰,刘小青,朱文静,薛春苗..基于数字化定量的高尿酸血症鹌鹑模型“四诊”证候研究[J].北京中医药大学学报,2013,36(5):317-321,后插1,6.基金项目
国家自然科学基金资助项目(No.81073068,81274153),北京中医药大学研究生自主立项课题(No.2011-JYBZZ-XS067),北京中医药大学科研创新团队项目(No.2011-CXTD-14) （No.81073068,81274153）
