重庆医学2013，Vol.42Issue(17)：1935-1938,4.DOI:10.3969/j.issn.1671-8348.2013.17.003
FolFox方案新辅助化疗对Ⅱ、Ⅲ期大肠癌手术患者血T-细胞亚群的影响
The impact of neoadjuvant chemotherapy with Folfox on T lymphoyte subsets in patients with Ⅱ , Ⅲ stage colorectal carcinoma
摘要
Abstract
Objective To investigate the neoadjuvant chemotherapy of FolFox regimen on Ⅱ,Ⅲ stage colorectal cancer operation patients blood T-cell subgroup effects and make a comparison study.Methods 65 cases of patients with colorectal cancer,underwent neoadjuvant chemotherapy of FolFox regimen,1 week after radical operation,all retention of anus success.According to the postoperative pathological results,more accurate grouping:Ⅱ stage 36 cases and Ⅲ stage 29 cases.Flow cytometry were used to detect the two groups of patients treated with neoadjuvant chemotherapy before 1 days,after seventh days and 14 days after transplantation of peripheral blood T lymphocyte cell subsets(CD3+,CD4+,CD8+,CD4+/CD8+) and contrast.Detection of 40 cases healthy human peripheral blood T lymphocyte cell subsets as health group to compare.Results Phase Ⅱ and Ⅲ group of patients treated with neoadjuvant chemotherapy before peripheral blood T lymphocyte cell subsets level contrast,at the same time with the healthy group,the differences were not statistically significant(P＞0.05) ;stage Ⅱ and stage Ⅲ group 7 days after operation in patients with peripheral T-cell subsets levels fell,stage Ⅲ group decreased obviously,both of the results and compared the difference was statistically significant(P＜0.05) ;stage Ⅱ and stage Ⅲ group 14 days after operation in patients with peripheral T-cell subsets levels have recovery,stage Ⅲ group recovery was slower,compared the differences were statistically significant(P＜0.05).Conclusion The FolFox regimens as neoadjuvant chemotherapy for colorectal cancer stage Ⅱ,serum levels of T lymphocyte subsets are affected,especially for colorectal cancer Ⅲ stage for greater impact,results in significant,prompting FolFox schemes in the neoadjuvant chemotherapy in the treatment of colorectal cancer in different stages in the process,on the immune function of patients with influence in the presence of adverse effects,clinical with stage Ⅲ colorectal cancer immune therapy over time in order to improve the clinical treatment effect.关键词
FolFox方案/结直肠肿瘤/新辅助化疗/T-细胞亚群Key words
FolFox/ colorectal neoplasms/ neoadjuvant chemotherapy/ T-cell subsets引用本文复制引用
朱其勇,黄海宁,吴可,梁建明,韦京君,尹刚,周莎,蒋荣刚,陈博..FolFox方案新辅助化疗对Ⅱ、Ⅲ期大肠癌手术患者血T-细胞亚群的影响[J].重庆医学,2013,42(17):1935-1938,4.基金项目
广西壮族自治区桂林市科技攻关基金资助项目(20080404). （20080404）
