重庆医学2013，Vol.42Issue(17)：1980-1982,3.DOI:10.3969/j.issn.1671-8348.2013.17.019
丝裂霉素纤维蛋白胶凝胶瘤内注射治疗裸鼠肝癌
Effects of intratumoral injection of mitomycin C mixing with fibrin glue on nude mice with liver cancer
摘要
Abstract
Objective To investigate the therapeutic effects of intratumoral injection of mitomycin C mixing with fibrin glue (MMC-FG) on nude mice with liver cancer and provide experimental foundation for its clinical application.Methods 30 nude mice with subcutaneous human hepatoma were randomized into five groups,in which MMC-FG was injected intratumorally(group A),MMC-FG injected intraperitoneally(group B),mitomycin C(MMC) injected intratumorally(group C),normal FG injected intratumorally(group D) and normal saline injected intratumorally(group E) respectively.After administation individual tumor growth was observed,tumor weight was scaled,inhibition ratio of tumor weight was calculated,and white blood count(WBC) and platelet(PLT)of peripheral blood of nude mice were examined.Other 50 nude mice with liver cancer were randomized into five groups in the same way.Survival time of individual nude mice was observed after administation likewise.Results The tumor volume of nude mice in group A increased the most slowly,whose inhibition ratio of tumor weight was 53.40％ and tumor weight was much lighter than that in other groups(P＜0.05).WBC and PLT of nude mice in group C were lower than those in group A(P＜0.05),while were similar with those in group B,D or group E(P＞0.05).Survival time of nude mice in group A was longer than that in other groups (P＜0.05).Conclusion Intratumoral injection of MMC-FG can inhibit tumor growth effectively,decrease toxicity of MMC,and prolong survival time of nude mice.It is an effective,safe and simple chemotherapeutic method.关键词
丝裂霉素/纤维蛋白组织黏着剂/肝肿瘤/药物疗法Key words
mitomycin/ fibrin tissue adhesive/ liver neoplasms/ drug therapy引用本文复制引用
殷香保,邬林泉,傅华群,罗志强,方路,章永恩..丝裂霉素纤维蛋白胶凝胶瘤内注射治疗裸鼠肝癌[J].重庆医学,2013,42(17):1980-1982,3.基金项目
江西省科学技术厅科技计划基金资助项目(2006) （2006）
江西省自然科学基金资助项目(2008GQY0050). （2008GQY0050）
