重庆医学2013，Vol.42Issue(18)：2120-2121,2.DOI:10.3969/j.issn.1671-8348.2013.18.022
胃癌组织中肿瘤转移抑制基因KISS-1的表达水平及对细胞外基质作用的研究
Research of tumor metastasis suppressor genes KISS-1 expression in stomach cancer tissue and it′s function to extracellular matrix
乌力吉白乙 1汤媛宇 2王宏伟2
作者信息
- 1. 内蒙古民族大学医学院病历科,内蒙古通辽,028000
- 2. 内蒙古通辽市科尔沁区第一人民医院病历科,028000
- 折叠
摘要
Abstract
Objective To observe tumor metastasis suppressor genes KISS-1 expression in stomach cancer tissue and it's function to extracellular matrix. Methods Collect 38 cases of patient's stomach organizations with stomach cancer and 38 cases of normal gastric mucosa tissue from January 2010 to February 2012 in our hospital, use RT-PCR tested the specimens KISS-1 expression in two groups, and testing various KISS-1 under positive level, the extracellular matrix (ECM ) differences in the level of expression. Results The positive rate of KISS-1 mRNA in stomach tissue is 56. 2%, in normal gastric mucosa tissue of the positive rate was 87.1%, the differences between them are statistically significant (P＜0.01).And according to the different expression level of KISS-1, ECM's main ingredients :laminin(LN ), Ⅳ protein collagen type and fibronectin (FN ) expressing a statistically significant difference( P＜0. 05 ). Conclusion KISS-1 and the occurrence and metastasis of cancer of the stomach is closely related, and through to the influence of the ECM expressed indirectly affects tumors and development process.关键词
胃肿瘤/细胞外基质/肿瘤转移抑制基因KISS-1/作用Key words
stomach neoplasms/ extracellular matrix/ tumor metastasis suppressor genes KISS-1/ function引用本文复制引用
乌力吉白乙,汤媛宇,王宏伟..胃癌组织中肿瘤转移抑制基因KISS-1的表达水平及对细胞外基质作用的研究[J].重庆医学,2013,42(18):2120-2121,2.
