南方医科大学学报2013，Vol.33Issue(6)：857-860,4.DOI:10.3969/j.issn.1673-4254.2013.06.14
基础状态血清高黄体生成素水平及黄体生成素/卵泡刺激素比值对多囊卵巢综合征患者体外受精妊娠结局的影响
Effect of basal serum luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio on outcomes of in vitro fertilization-embryo transfer in patients with polycystic ovarian syndrome
摘要
Abstract
Objective To evaluate the effect of basal serum luteinizing hormone (LH) and luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio on the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS).Methods A retrospective analysis was performed of 134 TWF cycles in patients with PCOS.The cycles were classified into 2 groups according to serum levels of LH and also into 2 groups according to LH/FSH ratio,namely group A1 (LH≤10 IU/L),group A2 (LH＞10 IU/L),group B1 (LH/FSH ratio＜2),and group B2 (LH/FSH ratio≥2).The clinical characteristics,embryological data and pregnancy outcomes were compared between the groups.Results Patients in group A2 showed significantly higher FSH,T level and LH/FSH ratio with a greater number of oocytes retrieved than those in group A1,but the time for down-regulation,duration of stimulation,AFC,LH and LH/FSH on the first day of stimulation,embryological data and pregnancy outcomes did not differ significantly between the two groups.Compared with group B1,group B2 showed higher basal LH,G level on the day of HCG,more oocytes retrieved and lower dose of gonadotropins used,but the time for down-regulation,duration of stimulation,LH and LH/FSH on the first day of stimulation and pregnancy outcomes were comparable between the two groups.Conclusion A high basal LH level or a high LH/FSH ratio does not produce obvious deleterious effect on the clinical outcomes of IVF-ET in women with PCOS who take oral contraceptives for pretreatment before long GnRH-agonist protocol.关键词
黄体生成素/卵泡刺激素/多囊卵巢综合征/体外受精-胚胎移植Key words
luteinizing hormone/ follicle-stimulating hormone/ polycystic ovary syndrome/ in vitro fertilization-embryo transfer引用本文复制引用
耿旭景,欧湘红,廖旖欣,谭雯雅,王松,全松..基础状态血清高黄体生成素水平及黄体生成素/卵泡刺激素比值对多囊卵巢综合征患者体外受精妊娠结局的影响[J].南方医科大学学报,2013,33(6):857-860,4.基金项目
国家自然科学基金(81170575) （81170575）
Supported by National Natural Science Foundation of China (81170575). （81170575）
