南方医科大学学报2013，Vol.33Issue(6)：926-929,4.DOI:10.3969/j.issn.1673-4254.2013.06.31
叶酸在预防胎源性子宫内膜异位症易感基因HOXA10异常甲基化中的作用
Effect of folic acid in preventing aberrant methylation of fetal endometriosis susceptibility gene HOXA10
摘要
Abstract
Objective To detect aberrant methylation in the promoter region of fetal endometriosis susceptibility gene homeobox-10 (HOXA10) in women with and without folic acid supplementation and explore the effect of folic acid in optimizing intrauterine environment.Methods Thirty-six cord blood specimens were collected between January,2010 and December,2012 from pregnant women with endometriosis,including 22 with folic acid treatment and 15 without.Methylation-specific polymerase chain reaction (MSP) and bisulfite salt modified sequencing (BSP) were employed to detect aberrant methylation of HOXA10 gene in these specimens.Results The methylation rate of HOXA10 gene differed significantly between pregnant women with endometriosis taking folic acid and those who did (P＜0.05).Conclusion Folic acid treatment can significantly reduce the methylation rate of fetal endometriosis susceptibility gene HOXA10.关键词
子宫内膜异位症/叶酸/甲基化/胎源性Key words
endometriosis/ folic acid/ methylation/ fetal origin引用本文复制引用
刘木彪,黄雪梅,许苏容,李蕾..叶酸在预防胎源性子宫内膜异位症易感基因HOXA10异常甲基化中的作用[J].南方医科大学学报,2013,33(6):926-929,4.基金项目
广东省科技计划面上项目(2010B031600094) （2010B031600094）
广东省医学科研指令性课题(C2010008) （C2010008）
省中医药局科研面上项目(2010228) （2010228）
广州市科技计划:民生与重大科技项目(11BppZXaaa 2120016) （11BppZXaaa 2120016）
