广东医学2013，Vol.34Issue(11)：1685-1688,4.
RAD51G135C单核苷酸多态性及其蛋白表达在非小细胞肺癌中的意义
The clinical significance of RAD51G135C single nucleotide polymorphisms and protein expression in non-small cell lung cancer
摘要
Abstract
Objective To investigate the RAD51G135C single nucleotide polymorphisms and RAD51 protein expression in non -small -cell lung carcinoma (NSCLC). Methods A total of 80 NSCLC cases and 40 controls with pulmonary non - neoplastic diseases were collected. The genotypes of RAD51G135C and the expression of RAD51 protein were analyzed by PCR - RFLP and immuonohistochemisty , respectively , for correlation analysis. Results The genotype fre -quencies of G/G, G/C and C/C were 83. 7% , 15. 0% and 7. 5% , respectively, in NSCLC patietns; and 92. 5% , 7. 5% and 0. 0% , respectively, in controls. When G/G served as the reference , there was significant increase risk of NSCLC of variant genotype (G/C and C/C, P <0. 05). The RAD51 over - expression incidence was significant higher (31.25% , 25/80) in NSCLC patients that in controls (2.5% , 1/40; P<0.05). Although the genotype of RAD51G135C was significantly correlated with the over - expression of RAD51 , there was no significant correlation between either of them and the clinicopathologic features of NSCLC (P >0. 05). Conclusion RAD51G135C single nucleotide polymorphisms and over -expression of RAD51 protein, which are closely correlated , are risk factors of NSCLC.关键词
非小细胞肺癌/RAD51G135C多态性/RAD51蛋白Key words
non -small cell lung cancer/ RAD51G135C polymorphisms/ RAD51 protein引用本文复制引用
陶雪勤,熊一峰,彭雅婷,梅金红..RAD51G135C单核苷酸多态性及其蛋白表达在非小细胞肺癌中的意义[J].广东医学,2013,34(11):1685-1688,4.基金项目
江西省医药卫生科研基金资助项目(编号:20113031) （编号:20113031）
