国际医药卫生导报2013，Vol.19Issue(9)：1381-1384,4.DOI:10.3760/cma.j.issn.1007-1245.2013.09.062
胰岛β细胞葡萄糖毒性分子机制的研究进展
Advances in molecular mechanisms of pancreatic beta-cell glucotoxicity
张珊珊 1吴木潮1
作者信息
- 1. 510120广州,中山大学孙逸仙纪念医院内分泌科
- 折叠
摘要
Abstract
The deterioration of beta-cell function and survival caused by chronic high glucose exposure is termed glucotoxicity.The mechanisms of pancreatic beta-cell glucotoxicity involve in oxidative stress,endoplasmic reticulum stress,mitochrondrial dysfunction,inflammation,advanced glycation end products,hypoxia and activation of HIF-1 α,and loss of differentiation in the alteration of beta-cell phenotype.The role of oxidative stress,endoplasmic reticulum stress,and loss of differentiation in the alteration of beta-cell phenotype is well ascertained.Oxidative stress is the central mechanism for glucotoxicity in pancreatic beta cells in diabetes.关键词
胰岛β细胞/葡萄糖毒性/分子机制Key words
Pancreatic beta-cell/Glucotoxicity/Molecular mechanism引用本文复制引用
张珊珊,吴木潮..胰岛β细胞葡萄糖毒性分子机制的研究进展[J].国际医药卫生导报,2013,19(9):1381-1384,4.
