国际医药卫生导报2013，Vol.19Issue(10)：1414-1417,4.DOI:10.3760/cma.j.issn.1007-1245.2013.10.010
时辰化疗方案与FOLFOX4方案治疗晚期肝癌的临床对比性研究
Clinical comparative analysis on chrono-chemotherapy and FOLFOX4 in the treatment of advanced primary hepatocellular cancer
摘要
Abstract
Objective To study the clinical effects and toxicity between chrono-chemotherapy of FOLFOX4 and conventional chemotherapy of in the treatment of advanced primary hepatocellular cancer.Methods Selecting 60 cases from Jan 2011 to Jun 2012 in our hospital.All of the cases were diagnosed as advanced primary hepatocellular cancer by pathological examination or histiocytes and then they were randomly divided into the control group (n=30,conventional chemotherapy of FOLFOX4) and the experimental group (n=30,chrono-chemotherapy of FOLFOX4),follow-up was conducted and we observed curative effect and complications of two groups,and compared the efficacy and safety.Results The control group had 5 cases of partial remission,16 cases of disease progression and others were stable,the experimental group had 13 cases of partial remission,8 cases of disease progression,9 stable cases.The adverse reactions were mainly bone marrow suppression,gastrointestinal reaction and liver/kidney damage,with majority of them in grade 1 or 2.The quality of life improvement of the experimental group was better than that of control group,showing statistical significant difference.Conclusion Chrono-chemotherapy of FOLFOX4 in treating advanced primary hepatocellular cancer,compared with that of conventional method,has better effect,lower adverse reaction and it is a preferable chemotherapy for clinical promotion.关键词
原发性肝癌/时辰化疗/毒副反应/对比Key words
Advanced primary hepatocellular cancer/ Chrono-chemotherapy/ Chemotherapy toxicity/Compare引用本文复制引用
吴庭安,梁卫群,王智辉,林大任,彭雨..时辰化疗方案与FOLFOX4方案治疗晚期肝癌的临床对比性研究[J].国际医药卫生导报,2013,19(10):1414-1417,4.基金项目
江门科技局科技计划项目([2011]89号) （[2011]89号）
