国际医药卫生导报2013，Vol.19Issue(10)：1454-1457,4.DOI:10.3760/cma.j.issn.1007-1245.2013.10.026
喷他佐辛超前镇痛预防瑞芬太尼全麻后痛觉过敏的ED50与ED95效果观察
ED50 and ED95 of pentazocine preemptive analgesia to prevent postoperative hyperalgesia in remifentanil-based anesthesia
颜志伟 1李建玉 1吴新文 1迮浩城1
作者信息
- 1. 510318广州,中国人民解放军第四二一医院麻醉科
- 折叠
摘要
Abstract
Objective To determin the 50％ effective dose (ED50) and 95％ effective dose (ED95) of pentazocine preemptive analgesia for preventing the postoperative hyperalgesia after remifentanil-based anesthesia.Methods 180 patients received laparoscopic cholecystectomy were randomly assigned to six pentazocine dose groups (0.10,0.14,0.19,0.26,0.36 and 0.5 mg/kg respectively).The pentazocine was infused by vein at the time of 10 minutes before the beginning of the surgery.Propofol and remifentanil were used for the general anaesthesia by endotracheal tube.Remifentanil was infused at 0.25 μ g/(kg · min).The feeling of pain was evaluated by visual analog scale (VAS) score at the time of 15 minutes after tracheal extubation (VAS＜4,the pentazocine was considered effective).To calculate the ED50 and ED95 to prevent hyperalgesia by using the Probit analysis method.Results The ED50 of pentazocine was 0.240mg/kg (95％CI:0.217 ～ 0.266 mg/kg) and ED95 was 0.473mg/kg(95％CI:0.402 ～ 0.607 mg/kg).Conclusion The ED50 and ED95 of pentazocine preemptive analgesia to prevent the postoperative hyperalgesia in laparoscopie cholecystectomy patients are 0.240 mg/kg and 0.473 mg/kg respectively.关键词
喷他佐辛/超前镇痛/瑞芬太尼/痛觉过敏/剂量效应关系Key words
Pentazocine/ Preemptive analgesia/ Remifentanil/ Hyperalgesia/ Dose-response relationship引用本文复制引用
颜志伟,李建玉,吴新文,迮浩城..喷他佐辛超前镇痛预防瑞芬太尼全麻后痛觉过敏的ED50与ED95效果观察[J].国际医药卫生导报,2013,19(10):1454-1457,4.
