国际医药卫生导报2013，Vol.19Issue(13)：1904-1907,4.DOI:10.3760/cma.j.issn.1007-1245.2013.13.005
罗格列酮对2型糖尿病患者血清脂联素、内脂素水平的影响
Effects of rogridone on serum levels of adiponectin and visfatin in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To explore the effects of rogridone on serum levels of adiponectin and visfatin in patients with type 2 diabetes mellitus (T2DM).Methods 95 patients with initial diagnosis of T2DM were randomly divided into two groups.The control group (40 patients) received education on diabetes,dietary intervention,exercise therapy,and oral mefformin sustained release tablets of 500 mg in the morning and at night separately with no other glycemia-effecting drugs,while the study group received rogridone of 4 mg daily in addition to the therapies used in the control group for 16 weeks.FBG,PBG,HbA1C,FINS,serum adiponectin and visfatin,and HOMA-IR were measured.Results Serum adiponectin level decreased sharply and level of visfatin increased significantly in patients with T2DM [(7.8 ± 3.2vs.3.2 ± 1.3) mg/L and (85.6 ± 18.5 vs.127.8 ± 20.1)μg/L,P＜0.01].Rogridone reduced levels of FBG,PBG,HbA1C,and FINS and improved HOMA-IR in the patients (P＜0.001).Serum adiponectin level markedly decreased and visfatin level obviously increased in the study group,as compared with the control group [(3.2 ± 0.9 vs.7.7 ± 2.1)mg/L and (125.3 ± 18.8 vs.79.3 ± 16.4) μ g/L,P＜0.01].Serum adponectin was negatively correlated with BMI,FPG,HOMA-IR,and visfatin (P＜0.01); visfatin level was positively related with BMI,FPG,and HOMA-IR (P＜0.01).Conclusions Rogridone can improve susceptibility of insulin and reduce insulin resistance to correct hyperinsulinemia and lower levels of blood sugar by regulating the changes in levels of serum adiponectin and visfatin.It is worth popularizing clinically.关键词
2型糖尿病(T2DM)/胰岛素抵抗/脂联素/内脂素/罗格列酮(Rosiglitazone)Key words
Type 2 Diabetes mellitus/Adiponectin/Visfatin/Rosiglitazone引用本文复制引用
王淑琴,王建勇,陈永谦,满洁..罗格列酮对2型糖尿病患者血清脂联素、内脂素水平的影响[J].国际医药卫生导报,2013,19(13):1904-1907,4.基金项目
东莞市科学技术局项目(201210515000727) （201210515000727）
