国际医药卫生导报2013，Vol.19Issue(13)：1997-1999,3.DOI:10.3760/cma.j.issn.1007-1245.2013.13.041
索拉非尼对肝癌术后早期肝功能及凝血功能影响的临床研究
Impacts of sorafenib on early liver function and blood coagulation in patients undergoing hepatectomy
黄超有 1张红卫 2聂向阳 1谢惠华1
作者信息
- 1. 511400广州,南方医科大学附属何贤纪念医院普外科
- 2. 510120广州,中山大学附属孙逸仙纪念医院肝胆外科
- 折叠
摘要
Abstract
Objective To investigate the impacts of sorafenib on liver function and blood coagulation in patients undergoing hepatectomy.Methods 30 patients with pathologically confirmed liver cancer received sorafenib at different doses.Liver function and blood coagulation were detected in all the patients before treatment and one and three months after treatment.Results There were no statistical significances among sorafenib at different doses in levels of AST,ALT,TBIL,IBIL,ALB,and PT (P＞0.05).Concentrations of ALT,AST,TBIL,IBIL,and ALB did not change statistically one month after treatment as compared with the baseline values (P＞0.05) while PT changed significantly (P＜0.05).There were no statistical significances in concentrations of TBIL,IBIL and ALB 3 month after treatment as compared with the baselines,but levels of ALT,AST,and PT differed significantly (P＜0.05).Conclusions Sorafenib can induce an early elevation in levels of transaminases in patients undergoing hepatectomy,which plays a role in the inhibition of blood coagulation in a dose-independent fashion.关键词
索拉非尼/肝癌术后/肝功能/凝血功能Key words
Sorafenib/Hepatectomy/Liver function/Blood coagulation引用本文复制引用
黄超有,张红卫,聂向阳,谢惠华..索拉非尼对肝癌术后早期肝功能及凝血功能影响的临床研究[J].国际医药卫生导报,2013,19(13):1997-1999,3.
