中国妇幼健康研究2013，Vol.24Issue(3)：279-282,4.DOI:10.3969/j.issn.1673-5293.2013.03.001
HIV感染孕产妇应用不同抗病毒药物方案对母婴传播的影响
Influence of different anti-retroviral drugs used by HIV infected pregnant women on mother-to-child transmission
摘要
Abstract
Objective To understand the influence of single and combination of anti -retroviral drags ( ARVs) used by HIV infected women on mother-to-child transmission of HIV. Methods From January 2005 to December 2008 , 1 120 HIV-1 infected mothers took use of ARVs in 23 county or districts medical institutions. They and their children were investigated with questionnaire and followed up . Structured questionnaires were used to collect information including anti -retroviral drag regimens , delivery mode , feeding pattern and HIV status of children bom to those HIV positive mothers. Results Compared with combined anti -retroviral regimens , women who received single dose of ARVs had highest risk of mother-to-child HIV transmission (6.92% ). Mother-to-child transmission rate of AIDS infected women with two combined antiretroviral regimens and with triple ARVs was 3.20% and 3.02% , respectively, which was significantly lower than that with single drug regimen (χ2= 8. 04,P = 0. 02). Conclusion In order to achieve better intervention effect on mother-to-child transmission of HIV/AIDS, single antiretroviral drags scheme should be avoided . The combination ARVs needs to be applied according to specific circumstance, and appropriate triple ARVs regimen should be popularized .关键词
艾滋病/母婴传播/抗逆转录病毒药物/联合药物方案/影响Key words
HIV/AIDS/ mother-to-child transmission/ antiretroviral drags (ARVs) / combination of ARVs / influence分类
医药卫生引用本文复制引用
王前,王临虹,方利文,吴久玲,王爱玲,王芳,王潇滟..HIV感染孕产妇应用不同抗病毒药物方案对母婴传播的影响[J].中国妇幼健康研究,2013,24(3):279-282,4.基金项目
国家"十五"科技攻关课题资助项目(2004BA719A03) （2004BA719A03）
