摘要
Abstract
Objective To investigate the clinical effects of different dose of carbetocin in prevention of postpartum hemorrhage (PPH) due to uterine atony and the drag safety. Methods Totally 320 cases of term pregnancy natural delivery were randomly divided into carbetocin group A, group B, group C and oxytocin group D. After delivery of fetus, intravenous carbetocin 75μg, 100μg and 125 μg were immediately given to group A , group B and group C , respectively. Intramuscular injection of 10 IU oxytocin was immediately given to group D, as well as infusion of 20 IU oxytocin. The time of third stage of labor, blood loss at birth, 2h and 24h after delivery after medication were compared among four groups , and the drag adverse reactions of medication were analyzed . Results The third labor time of group A , group B, group C was shorter than that of group D , and the bleeding volume at birth , 2h and 24h after delivery in these three groups was significantly less than that of group D . The differences were statistically significant ( t = 6. 38 ~ 17. 77 , all P < 0. 05). The blood loss of group B at birth, 2h and 24h after delivery was less than that of group A ( t value was 3. 25 , 2. 57 and 2. 37 , respectively , all P < 0. 05). Compared among carbetocin groups , there was no significant difference in blood loss at birth , 2h and 24h after delivery, and in the time of the third labor between group B and group C (t value was 1. 20, 0. 88 and 1. 86, respectively , all P > 0. 05 ). There were more cases with adverse reactions in group C than group B. Conclusion Intravenous injection of 100μg carbetocin immediately after fetal delivery can reduce the blood loss at birth and PPH , and shorten the third stage of labor. With less adverse reactions 100μg carbetocin is effective in preventing PPH and it is economic drag dosage .关键词
卡贝缩宫素/催产素/宫缩乏力/产后出血Key words
carbetocin/ oxytocin/ uterine atony/ postpartum hemorrhage (PPH)分类
医药卫生
