中国妇幼健康研究2013，Vol.24Issue(3)：384-385,397,3.DOI:10.3969/j.issn.1673-5293.2013.03.040
两种剂量LE和CC对PCOS不孕患者促排卵效果比较
Effect comparison of LE with two different doses and CC for ovulation induction in women with PCOS
王海燕 1郑鹏生 1曹浩哲 1陈梅 1贾志1
作者信息
- 1. 西安交通大学医学院第一附属医院生殖医学科,陕西,西安,710061
- 折叠
摘要
Abstract
Objective To compare the efficacy of two different doses of letrozole (LE) and clomiphene citrate ( CC) in the ovulation induction of infertile patients with polycystic ovary syndrome (PCOS). Methods A total of 179 infertile patients with PCOS were randomly divided into group A , B and C. Three groups were in order treated with LE 2.5mg/d (n = 80) , with LE 5.0mg/d (n =50) and with CC 100 mg/d (n =49) for five days from day 5 of menses. Ultrasonography was performed to monitor follicular development. Timed intercourse was performed after ovulation . On the hCG injection day , serum estradiol ( E2) , endometrium thickness , number of dominant follicles, single follicle rate, ovulation rate , pregnancy rate and the incidence of luteinized unmpture follicle syndrome ( LUFS) were observed. Results There were significant differences in endometrium thickness ( F = 6. 650,P=0. 002 < 0. 01) , E2 level ( F = 89. 533 , P =0. 000 <0. 01) and single follicle rate (χ2 = 7. 585 ,P = 0. 023 < 0. 05 ) on hCG day. The dominant follicles growth time , ovulation rate, pregnancy rate and incidence of LUFS were not significantly different among three groups (all P > 0. 05 ). Conclusion For the infertile patients with PCOS , the effect of two doses of LE on ovarian induction is similar to CC . The effect of 5.0mg/d of LE is not superior to that of 2. 5mg/d. Larger samples are needed for further study .关键词
来曲唑/克罗米芬/诱发排卵/多囊卵巢综合征Key words
letrozole ( LE) / clomiphene citrate (CC) / ovulation induction / polycystic ovary syndrome ( PCOS)分类
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王海燕,郑鹏生,曹浩哲,陈梅,贾志..两种剂量LE和CC对PCOS不孕患者促排卵效果比较[J].中国妇幼健康研究,2013,24(3):384-385,397,3.
