中国妇幼健康研究2013，Vol.24Issue(3)：427-428,440,3.DOI:10.3969/j.issn.1673-5293.2013.03.058
人参皂苷Rg3对EMs患者免疫功能的影响
Influence of ginsenoside Rg3 on immune function of patients with endometriosis
摘要
Abstract
Objective To compare the influence of ginsenoside Rg3 with that of gestrinone combined with surgery on immune function of patients with stage Ⅲ-Ⅳ endometriosis ( EMs). Methods A cohort of 100 conservative surgery patients with stage Ⅲ -Ⅳ EMs were assigned into two groups: study group (n =50) receiving ginsenoside Rg3 therapy (20mg, orally, once daily) for 3 successive months, and control group (n=50) treated with gestrinone (2. 5mg, orally, twice weekly) for 3 successive months, respectively. The level of T cell subsets and interleukin -6 (IL-6) were detected 1 month and 3 months after surgery. Results Study group was noted with obviously elevated serum CD3 T cell, CD3 CD8 T cell, CD4 /CD8 ratio at 1 month and 3 months after treatment compared with those before surgery, and the differences between study group and control group were significant (F value was 15. 877, 6. 437, 4. 227, 51. 956, 42.366 and 32.788, respectively, all P <0. 05). At 1 month and 3 months after surgery, CD3 CD4 ratio and IL-6 of study group decreased remarkably, and the differences between two groups were significant (F value was 19. 289, 39. 197, 6. 383 and 147.432, respectively, all P<0. 05). Conclusion Compared with gestrinone , ginsenoside Rg3 achieves higher efficacy in improving the immune function of EMs patients , and it is clinically effective adjuvant medication for patients with Ems .关键词
子宫内膜异位症/人参皂苷Rg3/孕三烯酮/免疫Key words
endometriosis (EMs) / ginsenoside Rg3 / gestrinone/ immunity分类
医药卫生引用本文复制引用
任艺婷,王莉娜,常涛,李兆艾..人参皂苷Rg3对EMs患者免疫功能的影响[J].中国妇幼健康研究,2013,24(3):427-428,440,3.基金项目
山西省卫生厅科技攻关计划资助项目(20100311102-2) （20100311102-2）
