摘要
Abstract
Objective To investigate the clinical effects of methotrexate (MTX) combined with mifepristone in the treatment of placenta accreta. Methods Retrospective analysis was conducted on the clinical data of 35 patients who were diagnosed with placenta accreta by pathological examination from February 28, 2007 to September 30, 2012 in Beihai Women and Children Health Hospital. According to different treatments , the patients were randomly divided into two groups: group A with 20 patients was treated with MTX and mifepristone , and group B with 15 patients was only observed. Two groups were compared in the aspects of postpartum hemorrhage , puerperal infection , hysterectomy, hCG becoming negative and residual placental tissue absorption . The relationship between the residual placental area and treatment course and drag toxicity response was observed . Results The incidence of postpartum hemorrhage in group A was lower than that in group B (χ2= 8.069,P =0.005). The incidence of hCG becoming negative and residual placental tissue absorption in group A was higher than those in group B (χ2 value was 10. 380 and 11. 091, respectively, P < 0. 05). The area of residual placenta was positively related with postpartum hemorrhage , puerperal infection , treatment course and drag toxicity response ( r=0. 8504 ,P < 0. 05). Conclusion Combination of MTX and mifepristone is effective to placenta accreta . However, the area of residual placental is large , the therapeutic effect is not ideal and adverse reactions increase .关键词
植入性胎盘/氨甲喋呤/米非司酮/产后出血Key words
placenta accreta / methotrexate ( MTX) / mifepristone/ postpartum hemorrhage分类
医药卫生
