国际生殖健康/计划生育杂志2013，Vol.32Issue(2)：136-139,4.
宫内高雄激素环境与子代多囊卵巢综合征
Prenatal Androgen Excessive Exposure related to Fetal Programming of Polycystic Ovary Syndrome
摘要
Abstract
Clinical,experimental and genetic evidence suggested that polycystic ovary syndrome (PCOS) could have an fetal origin of adult disease.During fetal development,prenatal androgens excess may intervene the epigenome,such as the altered DNA methylation and genomic imprinting,which may increase the later risk of PCOS.Exposure to androgens in utero induces a permanent PCOS-like phenotype characterized by hyperandrogenism,abnormal follicle development,luteinizing hormone hypersecretion from the reduced hypothalamic sensitivity to steroid negative feedback,and insulin resistance from the increased abdominal adiposity.The ability of prenatal androgens excess to alter the developmental trajectory of multiple organ systems could be one of early mechanisms of PCOS pathogenesis,which could be valuable for PCOS prevention in groups with high risks.关键词
多囊卵巢综合征/雄激素类/环境暴露/表现遗传Key words
Polycystic ovary syndrome/ Androgens/ Environmental exposure/ Epigenetics引用本文复制引用
严晓南..宫内高雄激素环境与子代多囊卵巢综合征[J].国际生殖健康/计划生育杂志,2013,32(2):136-139,4.基金项目
国家973计划项目(2012CB944902,2012CB944703) （2012CB944902,2012CB944703）
国家自然科学基金项目(81070465) （81070465）
