广西师范大学学报（自然科学版）2013，Vol.31Issue(2)：81-86,6.
一种新型希夫碱钯配合物的晶体结构及抗肿瘤活性研究
Crystal Structure and Antitumor Activity of a New Schiff Base Palladium Complex
摘要
Abstract
A new Schiff base 3,4-methylenedioxy-phenethylamine-pyridine-2-formaldehyde (L),was synthesized as ligand.The reaction of L with PdCl2 afforded the first palladium(Ⅱ) complex of L (complex 1).Complex 1 was characterized by IR,elemental analysis,ESI-MS,and structurally determined by Xray single crystal diffraction analysis.In vitro cytotoxicity test against six human tumor cell lines by MTT method showed that complex 1 exhibited significant cytotoxicity against the MDA-MB-231 tumor cell,with IC50 value of (6.98±1.43) μmol/L,while low cytotoxicity to the other five tumor cell lines (including A549,HeLa,NCI-H460,MGC80-3 and BEL7404),which indicated that complex 1 showed some cytotoxic selectivity on these tested tumor cell lines,suggesting its potential for the antitumoral applications.关键词
希夫碱/钯(Ⅱ)配合物/晶体结构/抗肿瘤活性Key words
Schiff base/palladium (Ⅱ) complex/crystal structure/antitumor activity分类
化学化工引用本文复制引用
陈思园,杨扬,彭艳,刘延成..一种新型希夫碱钯配合物的晶体结构及抗肿瘤活性研究[J].广西师范大学学报（自然科学版）,2013,31(2):81-86,6.基金项目
国家自然科学基金资助项目(21271051) （21271051）
广西医药产业人才小高地项目(1108) （1108）
药用资源化学与药物分子工程教育部重点实验室自主研究项目(CMEMR2012-A11) （CMEMR2012-A11）
