河北科技大学学报2013，Vol.34Issue(3)：224-229,6.DOI:10.7535/hbkd.2013yx03009
盐酸二甲双胍缓释骨架微丸的研制
Preparation of metformin hydrochloride sustained-release matrix pellets
摘要
Abstract
Metformin hydrochloride sustained-release matrix pellets are prepared by extrusion-spheronization method.The optimal operating conditions and formulation are obtained by single-factor and orthogonal experimental design.The micromeritic characteristics and the release in vitro of these pellets are evaluated.In the process,micro-crystal cellulose (MCC) is 10％,ethyl cellulose (EC) ∶ stearic acid=l∶ 1,and 2％ hypromellose(HPMC K4M) is used.The profiles of the prepared sustainedrelease pellets follow Higuchi equation,and have good sphericity.The developed process is reliable and the quality of the pellets is controllable.关键词
盐酸二甲双胍/骨架缓释微丸/挤出滚圆法/释放度Key words
metformin hydrochloride/ sustained-release matrix pellets/ extrusion-spheronization/ drug release分类
医药卫生引用本文复制引用
谢英花,胡易,马燕山,陈卉,侯东岳,孙勇军..盐酸二甲双胍缓释骨架微丸的研制[J].河北科技大学学报,2013,34(3):224-229,6.基金项目
河北省高等学校科学技术研究青年基金(2010241) （2010241）
河北省自然科学基金(C2011208081) （C2011208081）
