河北医学2013，Vol.19Issue(7)：968-971,4.DOI:10.3969/j.issn.1006-6233.2013.07.03
非对称性二甲基精氨酸在慢性心力衰竭发病过程中的作用机制研究
The Role of Asymmetric Dimethylarginine in Patients with Chronic Heart Failure
摘要
Abstract
Objective:To investigate the relevance between asymmetric dimethylarginine and nitric oxide during the pathogenesis of chronic heart failure patients,furtherly to study the molecular mechanism of both in chronic heart failure progression.Method:To test serum asymmetric dimethylarginine and NO concentrations of 60 patients with CHF and 60 healthy in control group,and test left ventricular parameters through ultrasound of CHF group and control group of healthy,and analyse the correlation.Then test the expression levels of DDAH gene and endothelial nitric oxide synthase gene in two groups by the fluorescence quantitative of PCR.Result:The asymmetric dimethylarginine and NO level of patients with chronic heart failure of cardiac function grading was significanctly different from the control group (P＜0.05).Asymmetric dimethylarginine levels were positively related to NYHA grading,and related negatively to left ventricular ejection fraction,in contrast to NO.In gene level matters,DDAH and nitric oxide synthase gene were negatively related to NYHA grading.Conclusion:Asymmetric dimethylarginine level is positively related to NYHA grading,which can be used as the index in the diagnosis of chronic heart failure.关键词
非对称性二甲基精氨酸/慢性心力衰竭/一氧化氮Key words
Asymmetric dimethylarginine/ Chronic heart failure/ Nitric oxide引用本文复制引用
黄俊喜,邹文姝,曾火才,曾燕,曾林源..非对称性二甲基精氨酸在慢性心力衰竭发病过程中的作用机制研究[J].河北医学,2013,19(7):968-971,4.基金项目
广东省河源市社会发展科技计划项目(项目编号:2012-083) （项目编号:2012-083）
