中医学报2013，Vol.28Issue(7)：981-983,3.
血府逐瘀汤对大鼠局灶性脑缺血模型的保护作用
Protective Effect of Xuefu Zhuyu Decoction for Focal Cerebral Ischemia
摘要
Abstract
Objective:To study the protective effect of Xuefu Zhuyu decoction for focal cerebral ischemia.Methods:Use line to establish middle cerebral artery occlusion model rats.Healthy adult male SD rats were randomly divided into blank control group,model control group,positive control group and therapeutic low dose group,middle dose group and high dose group,10 in each group.Determine the brain glutathione peroxidase (gsh-px),malondialdehyde (MDA) content,superoxide dismutase (SOD),catalase (CAT) and nitric oxide synthase(NOS) activity as well as behavioral score,blood rheology and histopathologic examination.Results:Each group of model rats showed obvious behavioral disorder.The behavior performance of therapeutic treatment group rats has a tendency to ease.The behavioral disorder of positive control group and therapeutic high dose group of rats had dramatically improved.The difference was statistically significant compared with model group(P ＜ 0.05).Compared with the blank control group,the whole blood viscosity,plasma viscosity and erythrocyte volume of model control group were significantly higher(P ＜ 0.05).Compared with model control group,the whole blood viscosity and plasma viscosity of each dose group were decreased significantly(P ＜ 0.05).The red blood cell volume of positive control group and therapeutic high dose group was decreased significanfly(P ＜ 0.05).Compared with blank control group,the MDA content and NOS activity of model control group were increased significantly but SOD,GSH-Px and CAT activity were decreased significantly (P ＜ 0.05).Compared with model control group,therapeutic treatment group can reduce MDA content and NOS activity in ischemic brain tissue as well as improve the SOD,GSH-Px and CAT activity(P ＜ 0.05).Conclusion:Xuefu Zhuyu Decoction can slow down the behavioral disorders of MCAO model,obviously improve the SOD,GSH-Px and CAT activity in ischemic brain tissue and decrease the MDA content as well as a tendency to reduce the NOS activity in ischemia brain tissue.Xuefu Zhuyu Decoction has certain protective effect on focal cerebral ischemia model.关键词
血府逐瘀汤/局灶性脑缺血/大鼠/行为学评分/血液流变学Key words
Xuefu Zhuyu decoction/ focal cerebral ischemia/ rat/ ethology score/ blood rheology分类
医药卫生引用本文复制引用
孙寒静,黎同明,王桂香..血府逐瘀汤对大鼠局灶性脑缺血模型的保护作用[J].中医学报,2013,28(7):981-983,3.基金项目
广东省自然科学基金项目(编号:K2100027) （编号:K2100027）
