湖南中医药大学学报2013，Vol.33Issue(5)：41-44,4.DOI:10.3969/j.issn.1674-070X.2013.05.011.041.04
益肺通络颗粒的主要药效学研究
Pharmacodynamic study of Yifei Tongluo granule
摘要
Abstract
Objective To study the effects of Yifei Tongluo granule on anti-tuberculosis,inhibit hypersensitivity,immune function and antitussive action.Methods Mouse model infected by Mycobacterium tuberculosis H37RV was selected to observe the anti-tuberculosis effect of Yifei Tongluo granule.The anti-allergic effect of Yifei Tongluo granule was evaluated by observing the swelling of right ear of mouse smeared with 2,4-dinitrochlorobenzene.The effects of Yifei Tongluo granule on the carbon clearance index and the ammonia liquor induced cough mice were observed.Results The lung,liver and spleen protection functions of Yifei Tongluo granule were obviously increased in medium and high dose groups (P＜0.01).Yifei Tongluo granule could markedly inhibited the ear swelling of mice.The carbon granule clearance index and correcting carbon clearance index in groups treated with Yifei Tongluo Granule were increased significantly than the blank control group(P＜0.01).The cough incubation period of mice induced by ammonia liquor was significantly prolonged and the cough times in 3 minutes were decreased by Yifei Tongluo granule.Conclusion Yifei Tongluo granule has the function of anti-tuberculosis,inhibiting hypersensitivity,enhancing immune and relieving cough.关键词
益肺通络颗粒/结核病/抑制超敏/耳肿胀度/炭粒廓清指数/校正廓清指数/小鼠模型Key words
Yifei Tongluo granule/ tuberculosis / inhibit hypersensitivity/ ear swelling degree/ carbon clearane index/ correcting carbon clearance index/ mouse model分类
医药卫生引用本文复制引用
欧艳,杨励,左亚杰,曾建国,刘艳科..益肺通络颗粒的主要药效学研究[J].湖南中医药大学学报,2013,33(5):41-44,4.基金项目
湖南省中医药科研计划重点课题资助项目(201113). （201113）
