华西口腔医学杂志2013，Vol.31Issue(3)：225-227,231,4.DOI:10.7518/hxkq.2013.03.002
尼古丁对大鼠不同部位骨钙磷含量和碱性磷酸酶活性的差异影响
The effects of nicotine on bone calcium and phosphorus content and alkaline phosphatase activity in different part of rat
摘要
Abstract
Objective To analyze the effects of nicotine on the bone calcium and phosphorus content and alkaline phosphatase (ALP) activity in rat alveolar bone and mandible.Methods Twenty health male Wistar rats of five weeks of age were randomly assigned to two groups and received daily intraperitoneal injections for three months as follows:Saline solution for control group,nicotine 0.73 mg·kg-1 ·d-1 for experimental group.The bone calcium phosphorus content were detected by concentrated acid digestion method and the ALP activity was examined by improved Reddi method.Results Compared to the control group,bone calcium and phosphorus content was lower in the experimental group (P＜0.05),ALP activity had no statistical significance (P＞0.05).Bone calcium phosphorus and ALP activity in different parts had no statistical significance (P＞0.05).Conclusion The nicotine reduces calcium phosphorus deposition of jaw bone,but has no obvious influence to ALP activity.关键词
尼古丁/牙槽骨/颌骨/钙/磷/碱性磷酸酶Key words
nicotine/alveolar bone/jaw bone/calcium/phosphorus/alkaline phosphatase分类
医药卫生引用本文复制引用
赵海霞,马肃,陈力,刘培红,徐晶,侯琳,陈蕊,秦春林..尼古丁对大鼠不同部位骨钙磷含量和碱性磷酸酶活性的差异影响[J].华西口腔医学杂志,2013,31(3):225-227,231,4.基金项目
黑龙江省科技厅攻关计划基金资助项目(GC05C416) （GC05C416）
哈尔滨市科技局优秀学科带头人基金资助项目(2009RFXXS214) （2009RFXXS214）
