摘要
Abstract
Objective To investigate the preventing effect of Fukang oral liquid(fuk) in intrauterine adhesions and its effects on the expression of TGFβ-1 、PAI 1 and MMP-9 in endometrium of rats with intrauterine adhesions.Methods 50 female wistar rats were divided into high,medium,low dose of Fukang oral liquid group (Hfuk,Mfuk,Lfuk),blank control group (Bcon),and model control group (Mcon) (n=10 in each group).The rats in Hfuk,Mfuk and Lfuk groups were treated with intragastric administration of 4 mL,2 mL and 1 mL Fukang Oral Liquid per day,while the rats in Mcon group and Bcon group received 2 mL physiological saline intragastric administration per day.All of rats were executed on 10th day and the sample of endometrium was harvested for the study of histology and morphology and the expression of TGFβ-1,PAI-1 and MMP-9.Results Under the light microscope,the organizational structure of the uterine cavity and uterine wall was clear in Beon group,the uterine cavity disappeared in Mcon group,and the layers structure remained normal arrangement in three fuk treated groups.TGFβ-1 and PAI-1 protein expressions in Hfuk,Mfuk,Lfuk groups were less than those in Mcon group (P＜0.001),but MMP-9 protein expressions were higher.(P＜ 0.001).Conclusion Fukang oral liquid show preventing effect on IUA,the mechanism may be related to its effects on the expressions of TGF-β1,PAI-1,and MMP-9 in the endometrium.关键词
宫腔粘连/妇康口服液/预防/转化生长因子-β1/纤溶酶原激活物抑制因子-1/基质金属蛋白酶-9Key words
Intrauterine adhesions/Fukang oral liquid/Precautions/TGF-β1/PAI-1/ MMP-9
