基础医学与临床2013，Vol.33Issue(7)：859-863,5.
乳腺癌中RIN1的表达及临床意义
The expression and clinical significance of RIN1 in breast cancer
摘要
Abstract
Objective To investigate the expression of RIN1 in breast cancer and to analyze its association with the prognosis.Methods To analyze the tissues from 85 breast cancer and 20 benign breast disease patients by immunhistochemical techniques,and followed up the 85 cases of breast cancer; RIN1 in 20 cases of breast cancer and adjacent tissues' expressions by Real Time PCR and Western blot assay.Kaplan-Meier survival analyzed the average survival time.Results A varying degrees of RIN1 were expressed in 85 cases of breast cancer,high expression in 44 cases,RIN1 was highly expressed in breast cancer than in non-cancer tissues(P ＜ 0.05);The expression of RIN1 was significantly associated with tumor size 、histological grade 、family history(P ＜ 0.05).The average survival period of high expression group was significantly shorter than that in low expression group (P ＜ 0.05).The high expression of RIN1 was related to the tumor disease-free survival (P ＜ 0.05).mRNA and protein were expressed in 20 cases of breast cancer and adjacent tissues.The expression of RIN1 mRNA and its protein significantly increased in cancer tissues.Conclusions RIN1 expression plays a role in breast cancer pathogenesis and Maybe its high expression could be used as a prognostic marker in breast cancer.关键词
乳腺癌/RIN1/预后Key words
breast cancer/ RIN1 / prognosis分类
医药卫生引用本文复制引用
梁欣洁,向庭秀,钟伟洋,张翔,厉红元..乳腺癌中RIN1的表达及临床意义[J].基础医学与临床,2013,33(7):859-863,5.基金项目
重庆市教委科学技术研究项目(KJ100317) （KJ100317）
