基础医学与临床2013，Vol.33Issue(7)：919-922,4.
斑马鱼——髓鞘损伤与再生研究的理想动物模型
Zebrafish: a novel animal model for demyelination and remyelination
摘要
Abstract
Multiple sclerosis is an immune-mediated disorder in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged,leading to demyelination and scarring as well as abroad spectrum of signs and symptoms.Zebrafish is an ideal model for investigating vertebrate demyelination and remyelination,due to the rapid external development and transparency of the embryos.Transgenic zebrafish allows visualization of cells in living zebrafish and provides a fast,real-time in vivo system for the analysis of gene expression patterns.关键词
脱髓鞘疾病/多发性硬化/斑马鱼/髓鞘再生Key words
demyelinating diseases/ multiple sclerosis/ zebrafish / remyelination分类
医药卫生引用本文复制引用
方杨武,李玉皓..斑马鱼——髓鞘损伤与再生研究的理想动物模型[J].基础医学与临床,2013,33(7):919-922,4.基金项目
国家科技支撑计划(2012BAI08B06) （2012BAI08B06）
国家自然科学基金(81250017) （81250017）
中央高校基本科研业务费(65122019) （65122019）
