解剖学杂志2013，Vol.36Issue(3)：353-356,4.DOI:10.3969/j.issn.1001-1633.2013.03.021
锌对神经病理性疼痛模型小鼠脊髓后角磷酸化的细胞外信号调节激酶表达的影响
Effect of zinc on the pERK expression in the spinal posterior horn of neuropathic pain mice
摘要
Abstract
Objective:To observe the effect of zinc on the expression of phosphorylative extracellular signal-regulate kinase (pERK) in the spinal posterior horn of neuropathic pain (NPP) model mice.Methods:Mice were divided into 4 groups:(1) a control group,normally fed mice were infected with physiological saline; (2) normally fed mice (2 weeks) were infected with capsaicin; (3) low level zinc fed mice (2 weeks) were infected with capsaicin; (4) high level zinc fed mice (2 weeks) were infected with capsaicin.Atomic absorption spectrum,heat pain threshold,immunohistochemistry and image analysis were used to test the effect of zinc on the behavior and expression of pERK in the spinal posterior horn of the model mice.Results:The level of zinc in the spinal cord and serum decreased after the normally fed mice had been injected with capsaicin,while the pERK in the spinal posterior horn and the thermohyperalgesia were increased.The deficiency of zinc in the serum and spinal was aggravated in low zinc fed,while the expression of pERK in the spinal posterior horn of the model mice and the thermohyperalgesia were increased.The zinc content in serum and spinal was increased in the high zinc fed mice,while the expression of pERK in the model mice the spinal posterior horn and the thermohyperalgesia were decreased.Conclusion:Zinc could inhibit the thermohyperalgesia and the pERK expression in the spinal posterior horn of NPP model and might take part in the formation and preservation of NPP.关键词
锌/神经病理性疼痛/脊髓/细胞外信号调节激酶Key words
zinc/ neuropathic pain/ spinal cord/ extracellular signal-regulate kinase引用本文复制引用
赵洪盈,张莉,郭敏..锌对神经病理性疼痛模型小鼠脊髓后角磷酸化的细胞外信号调节激酶表达的影响[J].解剖学杂志,2013,36(3):353-356,4.基金项目
辽宁省科技厅资助项目(20111118) （20111118）
辽宁医学院博士启动项目(Y2010B02) （Y2010B02）
