江苏大学学报（医学版）2013，Vol.23Issue(3)：247-253,7.
卟啉为核的星形聚己内酯-嵌段-聚乙二醇的合成及释放性能
Synthesis and release property of porphyrin-cored star-shaped poly (ε-caprolactone)-block-poly (ethylene glycol)
摘要
Abstract
Objective:In order to overcome the quenching of the traditional micromolecular porphyrin drug,the targeting polymer nanoparticles with porphyrin were obtained.Methods:Porphyrin-cored starshaped poly (caprolactone)-block-poly (ethylene glycol) copolymers (SPPCL-b-PEO) were synthesized via ring-opening polymerization and esterification reaction,and were characterized by gel permeation chromatograph,nuclear magnetic resonance spectrum,fourier transform infrared spectroscopy and ultraviolet visible spectroscopy.The photosensitizing efficiency of SPPCL-b-PEO investigated by fluorescence probe method.The self-assembly behavior of SPPCL-b-PEO was investigated by transmission electron microscope.The drug loading and release properties of SPPCL-b-PEO were studied by ultraviolet visible spectroscopy.Results:The polymeric poly (caprolactone)-block-poly (ethylene glycol) (PCL-PEO) skeleton can efficiently prevent self-quenching of the central porphyrin in the copolymers.The self-assembled aggregates changed from spherical micelles to worm-like micelles with decreasing the weight fraction of hydrophilic poly (ethylene glycol) (PEO) block in the copolymers.The Doxorubicin-loaded SPPCL-b-PEO nanospheres possess the high drug content and entrapment efficiency,and exhibit property of pH-induced drug release.Conclusion:SPPCL-b-PEO will not only provide potential porphyrin core for photodynamic therapy but also improve targeting to pH5 ～6 tumor tissues for drug delivery.关键词
开环聚合/酯化反应/卟啉/聚己内酯-聚乙二醇/多柔比星Key words
ring-opening polymerization / esterification reaction / porphyrin / PCL-PEO / doxorubicin-loaded nanospheres分类
化学化工引用本文复制引用
黄雅菲,戈延茹,戚雪勇,戴晓晖..卟啉为核的星形聚己内酯-嵌段-聚乙二醇的合成及释放性能[J].江苏大学学报（医学版）,2013,23(3):247-253,7.基金项目
国家自然科学基金资助项目(21004031) （21004031）
江苏省自然科学基金资助项目(BK2011459) （BK2011459）
江苏省博士后基金资助项目(1001034B) （1001034B）
