摘要
Abstract
Objective:To study the clinical efficacy and safety of tacrolimus combined with glucocorticoid on IgA nephropathy patients with moderate proteinuria.Methods:Twenty-five patients with IgA nephropathy were enrolled in the study and were randomly divided into two groups:single hormone group,14 cases were given single glucocorticoid treatment; combined treatment group,11 cases were given tacrolimus combined with glucocorticoid treatment.The changes of 24 h urine protein,aminotransferase,serum creatinine,serum glucose,blood pressure,treatment effects,and side effects were observed and compared between two groups before and 10 d,1 month,2 month,4 month,6 month after treatment.Results:There were no significant differences between two groups with regard to side effects of treatment; and the effect of tacrolimus combined with glucocorticoid were better than taking glucocorticoid singly on IgA nephropathy.Conclusion:When tacrolimus blood concentration fluctuates at 3.76-4.35 μg/L,it takes effect more quickly on IgA nephropathy patients with moderate proteinuria and has higher clinical remission rate.关键词
他克莫司/IgA肾病/糖皮质激素Key words
tacrolimus / IgA nephropathy / glucocorticoid分类
医药卫生
