昆明医科大学学报2013，Vol.34Issue(5)：4-6,13,4.
3,4-二氯-万古霉素手性固定相拆分克伦特罗和马布特罗对映体
Enantioseparation of Clenbuterol and Mabuterol on Self-made 3, 4-Dichlorovancomycin Chiral Stationary Phase
摘要
Abstract
Objective Using the polar mobile phase,the enantioseparation of clenbuterol and mabuterol on the self-made 3,4-dichlorovancomycin chiral stationary phase were studied.Methods The mobile phase was methanol,adding different proportions of acetic acid and triethylamine.The influence of different proportions of acid and alkali additives was investigated.The effects of column temperature and flow rate of mobile phase on the enantioseparation were also studied.Results With a mobile phase consisting of methanol ∶ aceticacid ∶ triethylamine =100 ∶ 0.05 ∶ 0.05 (Ⅴ∶Ⅴ∶Ⅴ) at a flow rate of 1.0 mL/min,the separation factor for clenbuterol and mabuterol were 1.232 and 1.299,and the resolution were 1.006 and 1.015,respectively.Conclusion The results indicated that the isomers of clenbuterol and mabuterol could be separated on self-made 3,4-dichlorovancomycin chiral stationary phase.关键词
3,4-二氯-万古霉素手性固定相/对映体拆分/克伦特罗/马布特罗Key words
3, 4-Dichlorovancomycin chiral stationary phase/ Enantioseparation/ Clenbuterol/Mabuterol分类
化学化工引用本文复制引用
郭伟,余小燕,谷晓娟,韩亚琼,沈报春..3,4-二氯-万古霉素手性固定相拆分克伦特罗和马布特罗对映体[J].昆明医科大学学报,2013,34(5):4-6,13,4.基金项目
国家自然科学基金资助项目(81102408) （81102408）
