昆明医科大学学报2013，Vol.34Issue(5)：23-28,6.
荷芩止痒搽剂止痒抗过敏作用的实验研究
Antipruritic and Antiallergic Effects of Heqin Zhiyang Liniment
摘要
Abstract
Objective This study was purposed to do a tentative exploration of the possible mechanisms responsible for relieving itching of Heqin Zhiyang liniment.Methods The inhibitory actions of Heqin Zhiyang liniment on pruritus in mice induced by 4-aminopyridine,dextran-40 and chloroquine,the effects on pruritus in guinea pigs induced by histamine phosphate monohydrate,the influences on capillary permeability in mice induced by histamine and the delayed type hypersensitivity (DTH) in mice induced by 2,4-dinitroch lorobenzol (DNCB) were observed,so that its potential antiallergic and antipruritic effects could be explore.Results Heqin Zhiyang liniment low,medium and high dose groups,all could effectively inhibit pruritus of guinea pig skin caused by histamine phosphate monohydrate.The medium and high dose groups could effectively inhibit the local capillary permeability caused by histamine phosphate monohydrate in mice.The low and medium dose groups had certain inhibitory effect on itchiness in mice caused by 4-aminopyridine and the production of IL-4 when chloroquine induced systemic pruritus scratch,but on grasping reactions of mice caused by dextran-40 and chloroquine and 2,4-dinitroch lorobenzol induced delayed hypersensitivity reaction were not obvious.Conclusion Heqin Zhiyang liniment has some antipruritic,antiinflammatory and antiallergic effects,and its mechanism might be related to the inhibition of local histamine release,reducing serum IL-4 and other inflammatory cytokines and the inhibition of local capillary permeability increase.关键词
荷芩止痒搽剂/止痒/抗过敏Key words
Heqin Zhiyang liniment/ Antipruritic / Antiallergic分类
医药卫生引用本文复制引用
赵景云,马克坚,陆宇惠,李蓉涛,方路,郭世民..荷芩止痒搽剂止痒抗过敏作用的实验研究[J].昆明医科大学学报,2013,34(5):23-28,6.基金项目
云南省科技厅应用基础研究基金资助项目(2009CD143) （2009CD143）
