摘要
Abstract
Objective To study the characteristics and related risk factors in the fibrinolytic system of non-obesity type 2 diabetic patients with pathological changes of blood vessels.Methods The case group included 134 non-obesity type 2 diabetic patients with vascular lesion; 80 healthy individuals were regarded as normal control group.The plasma level of thrombin-activatable fibrinolysis inhibitor (TAFI),plasminogen activator inhibitor-1 (PAI-1),von Willebrand factor (vWF)and fibrinogen (FIB) were measured.The level of fasting blood glucose,glycosylated hemoglobin,fasting insulin,body mass index and lipid metabolism indicators were detected as well.Results Compared with normal control group,the plasma level of TAFI (P ＜0.01),PAI-1 (P ＜0.05) in case group were obviously increased,and the plasma level of vWF (P ＜0.001),FIB (P ＜0.05)were also increased.The multifactorial logistic regression analysis showed that TAFI,PAI-1,vWF,glycosylated hemoglobin and triacylglycerol had positive correlation with vascular pathologies in non-obesity type 2 diabetic patients (P ＜0.05).Body mass index had negative correlation (P ＜0.05).Conclusion The activity of coagulation system could be enhanced in non-obesity type 2 diabetic patients,but the activity of fibrinolysis system was decreased.TAFI,PAI-1,vWF,glycosylated hemoglobin and triacylglycerol were independent risk factors of vascular pathologies.Conversely body mass index＜25 was a protective factor.关键词
凝血酶激活的纤溶抑制物/纤溶酶原激活剂抑制物-1/非肥胖型2型糖尿病Key words
thrombin-activatable fibrinolysis inhibitor/plasminogen activator inhibitor-1/non-obesity type 2 diabetic patients分类
医药卫生
