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三唑醇类化合物的合成及其抑菌性能的研究

李靖 刘幸平 程康华 崔爱玲 翟炜 燕乐乐

林产化学与工业2013,Vol.33Issue(3):115-119,5.
林产化学与工业2013,Vol.33Issue(3):115-119,5.DOI:10.3969/j.issn.0253-2417.2013.03.022

三唑醇类化合物的合成及其抑菌性能的研究

Synthesis and Antimicrobial Properties of Triazolanol Compounds

李靖 1刘幸平 1程康华 2崔爱玲 2翟炜 2燕乐乐1

作者信息

  • 1. 南京中医药大学药学院,江苏南京210046
  • 2. 南京林业大学化学工程学院,江苏南京210037
  • 折叠

摘要

Abstract

In order to find effective organic wood preservatives,the structure-activity relationship of triazolanol compounds was explored.Referencing to the chemical structure of tebuconazole,nine 1-(1H-1,2,4Vtriazol-1-yl)-2-(t-butyl)-3-substituted-2-propanol compounds were synthesized.They were characterized by MS and 1 H N MR,etc.In the range of 0.5 %-2%,their antimicrobial activity were evaluated by agar-well diffusion method for four kinds of wood spoilage bacteria.The expermental results showed that the para-substituted phenyl group is conducive to the antibacterial activity,and the target compounds have a good performance in anti-mildew.Moreover,the inhibitory effect of 4f against Trichoderma viride and wood-rotting fungi are considerable with tebuconazole.

关键词

三唑/三唑醇/合成/防腐性能

Key words

triazole/ triazolanol compounds/ synthesis/ antimicrobial activity

分类

化学化工

引用本文复制引用

李靖,刘幸平,程康华,崔爱玲,翟炜,燕乐乐..三唑醇类化合物的合成及其抑菌性能的研究[J].林产化学与工业,2013,33(3):115-119,5.

基金项目

国家林业局林业公益性行业专项(201104032) (201104032)

林产化学与工业

OA北大核心CSCDCSTPCD

0253-2417

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