临床口腔医学杂志2013，Vol.29Issue(6)：335-338,4.DOI:10.3969/j.issn.1003-1634.2013.06.006
血管化组织工程骨模型的体内构建
Prefabrication of vascularized tissue-engineered bone in vivo
摘要
Abstract
Objective:We pre-fabricated vascularized tissue-engineered bone in vivo with AV bundles,titanium cage and β-TCP and test the feasibility of the model.Method:The saphenous artery and vein (vessels) were dissected and muscle pouch was formed in the anteromedial aspect of left thigh.β-TCP+titanium cage+AV bundle were introduced into pouch of leg.At 1,2,3months,HE and CD31 immunohistochemical analyses were used to evaluate angiogenesis and new bone formation of the bone grafts.Result:The results of HE and immunohistochemical analysis indicated that there were new bone formation and vessel formation.Conclusion:Central AV bundle group could generate new bone formation and angiogenesis of tissue-engineered bone.This model was feasible for prefabrication of tissue-engineered bone in vivo.关键词
骨髓间充质干细胞/血管化/β-磷酸三钙/动静脉束Key words
bone marrow mesenchymal stem cells/ vascularization/ β-tricalcium phosphate ceramic/arteriovenous bundle分类
医药卫生引用本文复制引用
董智伟,刘彦普,鲍海宏,张力,朱浩,吕大为,杨涛,华泽权..血管化组织工程骨模型的体内构建[J].临床口腔医学杂志,2013,29(6):335-338,4.基金项目
辽宁省科技厅科技攻关课题(20122255014) （20122255014）
