临床神经外科杂志2013，Vol.10Issue(3)：139-141,3.DOI:10.3969/j.issn.1672-7770.2013.03.004
脑深部电刺激治疗帕金森病的长期随访研究
Long-term follow up of bilateral subthalamic nucleus stimulation for Parkinson' s disease cases
李建宇 1张宇清 1李勇杰1
作者信息
- 1. 10053 北京,首都医科大学宣武医院功能神经外科,北京市功能神经外科研究所
- 折叠
摘要
Abstract
Objective To present a large group of patients diagnosed with Parkinson' s disease (PD) who were treated with bilateral subthalamic nucleus (STN) deep brain stimulation (DBS).Methods 195 consecutive patients who received implants at our institution for bilateral stimulation of the subthalamic nucleus.Macrostimulation and microrecording for STN identification were used in all cases.Patients were assessed at 1,3,and 5 years with levodopa (on medication) and without levodopa (off medication),with use of the Unified Parkinson' s Disease Rating Scale.Results As compared with base line,the patients' scores at five years for motor function while off medication improved by 60.3％ and those for activities of daily living improved by 54.2％.Speech was the only motor function for which off medication scores did not improve.The scores for motor function on medication did not improve one year after surgery,except for the dyskinesia scores.On-medication akinesia,speech,postural stability,and freezing of gait worsened between 1 year and 5 years.At five years,the dose of dopaminergic treatment and the duration and severity of levodopa-induced dyskinesia were reduced as compared with base line.Conclusions Patients with advanced PD who were treated with bilateral stimulation of the subthalamic nucleus had marked improvements over long-term follow up in motor function while off medication and in dyskinesia while on medication.There was no control group,but worsening of akinesia,speech,postural stability,freezing of gait,and cognitive function between the first and the fifth year is consistent with the natural history of PD.关键词
帕金森病/脑深部电刺激/丘脑底核Key words
Parkinson' s disease / deep brain stimulation / subthalamic nucleus分类
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李建宇,张宇清,李勇杰..脑深部电刺激治疗帕金森病的长期随访研究[J].临床神经外科杂志,2013,10(3):139-141,3.
