临床神经外科杂志2013，Vol.10Issue(3)：152-155,4.DOI:10.3969/j.issn.1672-7770.2013.03.008
结缔组织生长因子表达水平与垂体腺瘤侵袭性之间关系
Difference of expression level of connective tissue growth factor between pituitary adenoma and aggressive pituitary adenoma
康现鑫 1赵天书 1董白晶 1汤加斌 1林祖岩 1刘晓谦1
作者信息
- 1. 150001 哈尔滨医科大学附属第四医院神经外科
- 折叠
摘要
Abstract
Objective To investigate the relationship between the expression of connective tissue growth factor(CTGF) and aggressive of human pituitary adenom,that provides the theoretical basis for the biological treatment of pituitary adenoma.Methods Quantitative real time PCR (qRTPCR) and Western blot were used to detecte the expression of CTGF in 16 cases of non-invasive pituitary adenoma and 52 cases of invasive pituitary adenoma(IPA).Results CTGF expression was found in all cases of invasive pituitary adenomas and noninvasive pituitary adenomas.The expression of CTGF in invasive pituitary adenoma was higher than that of in noninvasive pituitary adenoma(P =0.01).Conclusions The expression of CTGF in invasive pituitary adenoma is significantly higher than that of in the noninvasive pituitary adenoma and related with the size of pituitary adenoma.关键词
侵袭性垂体腺/结缔组织生长因子/实时定量聚合酶链反应/蛋白免疫印记杂交Key words
invasive pituitary adenoma/ connective tissue growth factor/ real time PCR/Western blot分类
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康现鑫,赵天书,董白晶,汤加斌,林祖岩,刘晓谦..结缔组织生长因子表达水平与垂体腺瘤侵袭性之间关系[J].临床神经外科杂志,2013,10(3):152-155,4.
