临床误诊误治2013，Vol.26Issue(6)：83-85,3.DOI:10.3969/j.issn.1002-3429.2013.06.037
血清MMP-3和TIMP-1水平在子宫内膜异位症诊断中的意义
Diagnostic Value of Levels of Serum Matrix Metalloproteinase-3 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Patients with Endometriosis
岳庆阳 1解芳 2张丽红 1刘民力1
作者信息
- 1. 110003沈阳,解放军第202医院体检中心
- 2. 110001沈阳,中国医科大学高等职业技术学院
- 折叠
摘要
Abstract
Objective To evaluate significance of levels of serum matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in diagnosis of endometriosis.Methods A total of 46 patients with endometriosis (observation group) and 40 healthy women (control group) were recruited in this study.Serum levels of MMP-3 and TIMP-1 in the two groups were measured and compared.Results Serum levels of MMP-3 and TIMP-I in observation group were (139.7 ±71.0)μg/L and (340.8 ± 111.5)μg/L,and (70.5 ±32.0)μg/L and (188.9 ±72.8)μg/L in control group respectively.The differences of the two groups were statistically significant (P ＜ 0.01).Area under receiver operating characteristic (ROC) curves of serum MMP-3 and TIMP-1 were 0.831 and 0.864 respectively (P ＜ 0.01).The sensitivity of combined detection of serum MMP-3 and TIMP-1 was 97.4％,and specificity was 96.3％.Serum levels of TIMP-1 showed positive correlation with MMP-3 (r =0.5003,P ＜0.01).Conclusion MMP-3 and TIMP-1 may be related to the progression of endometriosis,and serum levels of MMP-3 and TIMP-1 may be helpful in diagnosis and adjuvant approaches of endometriosis.关键词
子宫内膜异位症/基质金属蛋白酶3/基质金属蛋白酶组织抑制因子1Key words
Endometriosis/ Matrix metalloproteinase-3/ Tissue inhibitor of matrix metalloproteinase-1分类
医药卫生引用本文复制引用
岳庆阳,解芳,张丽红,刘民力..血清MMP-3和TIMP-1水平在子宫内膜异位症诊断中的意义[J].临床误诊误治,2013,26(6):83-85,3.
