环境与职业医学2013，Vol.30Issue(6)：405-410,6.
某地区2岁幼儿的邻苯二甲酸酯暴露水平及其影响因素
Levels and Influencing Factors of Phthalates Exposure in Two-Year-Old Infants in a County
摘要
Abstract
To evaluate exposure levels of phthalates and its influencing factors in infants at the age of 2 years old.[Methods] Questionnaires and spot urine samples were collected from 344 2-year-old infants in a county of Jiangsu Province from June 2011 to January 2012.The survey content included infants' general information and their behaviors & habits with potential exposure to phthalates.Nine urinary phthalate metabolites were determined by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).Non-parametric test and multiple linear regression analysis were used to identify the influencing factors of infant phthalates exposure.[Results] The phthalate metabolites were identified in all urine samples of these infants.The median levels were as follows:monomethyl phthalate (MMP),15.73 μg/L; monoethyl phthalate (MEP),13.99 μg/L; monobutyl phthalate (MBP),39.30 μg/L; monoisobutyl phthalate (MiBP),29.23μg/L; mono-3-carboxypropyl phthalate (MCPP),2.90 μg/L; mono-2-ethylhexyl phthalate (MEHP),2.88 μg/L; mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP),11.93 μg/L;mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP),8.70 μg/L,and mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP),50.10 μg/L.The positive rates were 100.00％ for MMP,MEHHP,and MECPP,respectively; 89.80％ for MEHP; and 96.80％-99.71％ for the other 5 metabolites.The usage of plastic milk bottles or plastic tableware was found to have statistically significant effects on concentrations of some urinary phthalate metabolites in infants' urine samples (P＜0.05).[Conclusion] The findings suggest that the infants are widely exposed to phthalates.The usage of plastic milk bottles or plastic tableware might increase infants' exposure to phthalates.关键词
邻苯二甲酸酯/尿/高效液相色谱-串联质谱/幼儿Key words
phthalates/ urine/ high performance liquid chromatography-tandem mass spectrometry/ infants分类
医药卫生引用本文复制引用
朱效宁,金玉娥,邬春华,汪国权,常秀丽,卢大胜,周志俊..某地区2岁幼儿的邻苯二甲酸酯暴露水平及其影响因素[J].环境与职业医学,2013,30(6):405-410,6.基金项目
上海市公共卫生重点学科建设项目(编号:08GWZX0303、08GWD20) （编号:08GWZX0303、08GWD20）
