南京理工大学学报（自然科学版）2013，Vol.37Issue(3)：453-456,4.
不同剂量舒芬太尼对大鼠麻醉及恢复的影响
Influence of different doses of sufentanil on anesthesia and recovery in rats
李金凤 1高昭 1王建民 2陈魁君 2赵卓1
作者信息
- 1. 北京理工大学机电学院,北京100081
- 2. 第三军医大学野战外科研究所,重庆400042
- 折叠
摘要
Abstract
To compare the influence of different doses of sufentanil administrated intraperitoneally on anesthesia and recovery in rats,sixty adult SD rats are randomly divided into 5 groups(S1 ～ S5).Rats in S1 ～ S5 are given a single intraperitoneal injection of sufentanil 50,60,150,250 and 400 μg/kg body weight respectively.The loss of righting reflex (LRR),the duration of post-LRR ataxia and the grip time in the duration of the post-LRR ataxia are recorded,and the anesthesia depth is assessed.The data of statistics analysis show that LRR rate in S2 ～S5 are 100％,whereas in S1 is 83.3％.With the increase of dose administrated,the time for induction of LRR decreased,the depth of anesthesia increased,the duration of LRR and post-LRR ataxia are prolonged and the time of grip is reduced.The results demonstrate that the effect of sufentanil administrated intraperitoneally on anesthesia and recovery in rats presents dose-dependence,and sufentanil in the dose of 60 ～ 150 μg/kg provides optimal depth of anesthesia and recovery quality.关键词
舒芬太尼/剂量/麻醉/麻醉恢复/大鼠Key words
sufentanil/doses/anesthesia/recovery/rats分类
医药卫生引用本文复制引用
李金凤,高昭,王建民,陈魁君,赵卓..不同剂量舒芬太尼对大鼠麻醉及恢复的影响[J].南京理工大学学报（自然科学版）,2013,37(3):453-456,4.
