南京医科大学学报（自然科学版）2013，Vol.33Issue(6)：788-791,4.DOI:10.7655/NYDXBNS20130614
冠心病患者阿司匹林与氯吡格雷抵抗发生情况的调查研究
Incidence of aspirin and clopidogrel resistance in patients with coronary artery disease
摘要
Abstract
Objective:To investigate the incidence of aspirin and clopidogrel resistance in patients with coronary artery disease received percutaneous coronary intervention (PCI),and provide evidence for the individualized anti-platelet treatment.Methods:Two hundreds patients with defined coronary artery disease who have received PCI were recruited in this study.Platelet aggregations (PLAA and PLADP) 1 mmol/L arachidonic acid(AA) and 5 μmol/L adenosine diphosphate(ADP) were determined using the light transmission aggregometer(LTA).Aspirin and clopidogrel resistance were defined as PLAA ＞20％ and PLADP ＞40％,respectively.Results:None of the patients was resistant to aspirin in the recruited subjects;the mean PLAA of the recruited patients was (2.63 ± 2.40)％.Forty four patients (22.0％) were resistant to clopidogrel,and the mean PLADP of the non-responders was (47.16 ± 5.82)％ ;by contrast,156 patients (78.0％) were sensitive to clopidogrel,and the mean PLADP of the responders was (25.62 ± 8.71)％.Conclusion:Aspirin resistance is rare,while clopidogrel resistance is much common in patients with coronary artery disease,which suggests that individualized anti-olatelet treatment should be initiated targeting patients with clopidogrel resistance.关键词
冠心病/阿司匹林抵抗/氯吡格雷抵抗/血小板聚集率Key words
coronary artery disease/ aspirin resistance / clopidogrel resistance/ platelet aggregation分类
医药卫生引用本文复制引用
孔德玉,陈俊,李春坚,朱甜甜,张秋,刘洁,龚晓璇,张定国,贾恩志..冠心病患者阿司匹林与氯吡格雷抵抗发生情况的调查研究[J].南京医科大学学报（自然科学版）,2013,33(6):788-791,4.基金项目
国家自然科学基金资助(81170181) （81170181）
