内科理论与实践2013，Vol.8Issue(3)：200-203,4.DOI:10.3969/j.issn.1673-6087.2013.03.011
复方丹参滴丸对冠心病患者阿司匹林抵抗的作用
Effect of compound Danshen dripping pill on asiprin resistance in patients with coronary artery disease
张弦 1吴春芳 1陆国平1
作者信息
- 1. 上海交通大学医学院附属瑞金医院心内科,上海200025
- 折叠
摘要
Abstract
Objective To investigate the effect of compound Danshen dripping pill on aspirin resistance (AR) tested by arachidonic acid (AA) and adenosine diphosphate (ADP) induced platelet aggregation in patients with coronary artery disease.Methods A total of 39 coronary artery disease patients with AR were randomly assigned into group A (n=19) treated with aspirin alone and group B (n=20) treated with a combination of aspirin and compound Danshen dripping pill.AA and ADP induced platelet aggregation rates were measured before and one month after treatment,and the results were compared.Results In group B,AA and ADP induced platelet aggregation rate was significantly lower after one month treatment than that before treatment (69.46％±5.18％ vs.73.81％±2.86％,P=0.048 9); blood uric acid level was significantly lower after one month treatment than that before treatment[(421.69±34.01) μmol/L vs.(444.69±50.88) μmol/L,P=0.038 9],which was also lower than that in group A [(444.88±21.32) μmol/L,P=0.042 2].No adverse event was observed in both groups.Conclusions Compound Danshen dripping pill has anti-platelet effect in coronary artery disease patient with AR,and can reduce uric acid level.关键词
阿司匹林抵抗/复方丹参滴丸/血小板聚集率/尿酸Key words
Aspirin resistance/Compound Danshen dripping pill/Platelet aggregation/Blood uric acid分类
医药卫生引用本文复制引用
张弦,吴春芳,陆国平..复方丹参滴丸对冠心病患者阿司匹林抵抗的作用[J].内科理论与实践,2013,8(3):200-203,4.
