农药学学报2013，Vol.15Issue(3)：250-255,6.DOI:10.3969/j.issn.1008-7303.2013.03.02
(4-亚甲基-5-羰基-3-四氢呋喃基)-苯甲酸甲酯衍生物的合成及其杀菌活性
Synthesis and fungicidal activity of (4-methylene-5-oxotetrahydrofuran-3-yl) methyl benzoate derivatives
摘要
Abstract
In order to elucidate structure-activity relationship of natural product Cedarmycins,a series of novel (4-methylene-5-oxo-tetrahydrofuran-3-yl) methyl benzoate derivatives (2a-2s) were synthesized by condensation of 4-(hydroxymethyl)-5-methylene-dihydrofuran-2 (3H)-one with various substituted benzoate acids.The preliminary bioassay showed that some of these compounds have good fungicidal activity,especially against Rhizoctonia solani and Phytophthora capsici.The EC50 value of compound 2e(R =2,4-2C1) were about 1.6 mg/L for the above fungus.关键词
Cedarmycins衍生物/α-亚甲基-β-羟甲基-γ-丁内酯苯甲酸酯/合成/杀菌活性Key words
(4-methylene-5-oxo-tetrahydrofuran-3-yl) methyl benzoate/ cedarmycin/ synthesis/fungicidal activity分类
化学化工引用本文复制引用
谢龙观,王娇,崔庆,张煦,徐效华..(4-亚甲基-5-羰基-3-四氢呋喃基)-苯甲酸甲酯衍生物的合成及其杀菌活性[J].农药学学报,2013,15(3):250-255,6.基金项目
国家自然科学基金资助项目(20872070). （20872070）
