农药学学报2013，Vol.15Issue(3)：359-362,4.DOI:10.3969/j.issn.1008-7303.2013.03.20
2-(苯并异噻唑啉-3-酮-2-基)芳香酯类化合物的合成及生物活性
Synthesis and antibacterial activity of 2-(3-oxobenzo[d] isothiazol-2(3H)-yl) ethyl benzoates
摘要
Abstract
Six novel 2-(3-oxobenzo [d] isothiazol-2 (3H)-yl) ethyl benzoates were synthesized bycondensation of 2-(2-hydroxyethyl) benzo [d] isothiazol-3 (2H)-one with substituted benzoic acids.All compounds were characterized by IR,1H NMR,ESI-MS and elemental analysis.The organisms used in the biological activity assay included gram-positive bacteria (Bacillus subtilis,Staphylococcus aureus,Staphylococcus albus) and gram-negative bacteria (Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa).The results showed that most of the compounds exhibit excellent inhibition activity against B.subtilis and S.aureus with MIC50 value about 4 mg/L.关键词
N-羟乙基苯并异噻唑啉-3-酮/合成/抑菌活性Key words
2-(2-hydroxyethyl) benzo[d] isothiazol-3 (2H)-one/ synthesis/ antibacterial activity分类
化学化工引用本文复制引用
王向辉,林强,郭智芳,邵艳东,朱林华..2-(苯并异噻唑啉-3-酮-2-基)芳香酯类化合物的合成及生物活性[J].农药学学报,2013,15(3):359-362,4.基金项目
国家自然科学基金项目(20962007). （20962007）
