四川医学2013，Vol.34Issue(2)：236-237,2.
新辅助化疗对乳腺癌患者雌激素、孕激素受体表达的影响及其临床意义
The affection of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast cancer patients and its clinical significance
金雪瑛 1田欣1
作者信息
- 1. 中国医科大学附属盛京医院第二肿瘤科,辽宁沈阳110000
- 折叠
摘要
Abstract
Objective To observe the affection of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast cancer patients and its clinical significance. Methods From October 2009 to October 2011, the expression of ER and PR were detected by immunohistochemical methods in 128 cases with breast cancer patients. Results In 128 cases with breast cancer, 14 were CR, accounting for 10.9% , 87 were PR, accounting for 68. 0% , 17 were SD, accounting for 13. 3% , 10 were CR, accounting for 7. 8%. The rate of CR + PR in negative group was significantly higher than that in positive(P <0. 05). After treatment, the positive rate of ER and PR in CR + PR group was significantly decreased(P < 0. 05 ), while no significant difference in SD + PD group( P > 0. 05). The positive rates of ER and PR in CR + PR group before and after treatment were significantly lower than those in SD + PD group( P < 0. 05 ). Conclusion The breast cancer patients with negative expression of ER and PR are more sensitive to neoadjuvant chemotherapy, and the neoadjuvant chemotherapy also can change the expression status of ER and PR.关键词
新辅助化疗/乳腺癌/雌激素受体/孕激素受体Key words
neoadjuvant chemotherapy/ breast cancer/ estrogen receptor/ progesterone receptor分类
医药卫生引用本文复制引用
金雪瑛,田欣..新辅助化疗对乳腺癌患者雌激素、孕激素受体表达的影响及其临床意义[J].四川医学,2013,34(2):236-237,2.
