山东医药2013，Vol.53Issue(13)：5-7,10,4.DOI:10.3969/j.issn.1002-266X.2013.13.002
颈内动脉闭塞患者临床表现与侧支循环的关系及其影响因素
The relationship between clinical manifestations and collateral circulation and its factors in patients with internal carotid artery occlusion
摘要
Abstract
Objective To investigate the relationship between clinical manifestations and collateral circulation and its related factors in patients with internal carotid artery occlusion (ICAO).Methods 63 patients with ICAO were analyzed retrospectively.According to the clinical manifestations,all patients were divided into three groups:asymptomatic group(n =14),TIA group (n =4) and cerebral infarction group (n =45).According to the building of collateral circulation,all patients were divided into two groups:the better compensation group (n =42) and the poorer compensation group (n =21).According to cerebral infarction,all patients were divided into two groups:the cerebral infarction group (n =45) and no cerebral infarction group (n =18).CT angiography (CTA) and Transcranial Doppler (TCD) were used to evaluate collateral circulation and the risk factors.The relationship between clinical manifestations and collateral circulation and its related factors were discussed Results ①The opening of primary collateral pathways (AComA and PComA) had the most frequency of the three groups,the secondary collateral pathways(OA) was the second.No statistically significance was found among three groups.②The hyperlipidemia percentage and the high-sensitivity C-reactive protein(hs-CRP) level of the poorer compensation group were higher than those of the better compensation group(P ＜ 0.05).③For coronary heart disease,cerebral infarction group was significantly lower than that of no cerebral infarction group (P ＜ 0.05),but for hs-CRP,cerebral infarction group was significantly higher than that of no cerebral infarction group (P ＜ 0.01).Conclusions There is no significant relativity between clinical manifestations and collateral circulation in patients with ICAO.Hyperlipidemia and inflammatory factor influence the establishment of collateral circulation and formation of cerebral infarction,which participate in the pathophysiological process of ICAO,so we should strengthen the control of risk factors and inflammation of ICAO patients.关键词
颈内动脉闭塞/临床表现/侧支循环/影响因素Key words
internal carotid artery occlusion/ clinical manifestations/ collateral circulation/ factors分类
医药卫生引用本文复制引用
王洪坤,姜振泼,宋玉强,张拥波..颈内动脉闭塞患者临床表现与侧支循环的关系及其影响因素[J].山东医药,2013,53(13):5-7,10,4.基金项目
山东省自然科学基金资助项目(ZR2009CM136). （ZR2009CM136）
