山东医药2013，Vol.53Issue(20)：1-3,3.DOI:10.3969/j.issn.1002-266X.2013.20.001
HIF-1α基因3'非编码区多态性与胰腺癌发生发展的相关研究
Association of polymorphism in the 3' untranslated region of hypoxia-inducible factor-1α gene with the susceptibility and progression of pancreatic cancer
摘要
Abstract
Objective To investigate whether the polymorphisms of hypoxia-inducible factor 1 alpha (HIF-1) in 3'untranslated region are involved in the susceptibility and progression of pancreatic cancer (PC).Methods The association between the genotype distribution of HIF-1 in 3' untranslated region rs2057482 SNP and the risk of PC,and the influence on clinicopathological features of PC were analyzed in a hospital-based,case-control study,which included 291 patients with PC and 247 controls.Genotypes of HIF-I were determined by polymerase chain reaction(PCR) and sequence analysis.Results The C/C genotype distributions of HIF-1 α gene rs2057482 were 73.5％ in patients with PC and 61.9％in controls,with a significant difference; the C/T +T/T distributions were 26.5％ in patients with PC and 38.1％ in controls (P ＜ 0.01).Heterozygous genotype (C/C) of the rs2057482 polymorphism had a higher risk of developing PC,compared with homozygous genotype (C/T + T/T) (OR =1.684,95％ CI:1.242-2.314).By performing Logistic analysis,the survival time of PC patients carrying C/C genotype (14.0 ± 2.1 months) was significantly lower than those of C/T + T/T genotype (25.2 ±6.3 months,P =0.01).And significant difference was found in lymph node metastasis between C/T +T/T and C/C groups (P＜0.05).Conclusion This study suggests that the HIF-1 rs2057482 SNP in 3' untranslated region confer susceptibility and progression to pancreatic carcinogenesis.关键词
胰腺癌/缺氧诱导因子1α/基因多态性/3'非编码区Key words
pancreatic carcinoma/ hypoxia-inducible factor-1 alpha/ polymorphism/ 3'untrans lated region分类
医药卫生引用本文复制引用
张圣杰,王秀超,贾玲玲,任贺,郝继辉..HIF-1α基因3'非编码区多态性与胰腺癌发生发展的相关研究[J].山东医药,2013,53(20):1-3,3.基金项目
国家自然科学基金资助项目(30973490,30900596,30901448,81172355). （30973490,30900596,30901448,81172355）
