山东医药2013，Vol.53Issue(20)：18-21,4.DOI:10.3969/j.issn.1002-266X.2013.20.006
广西红水河流域壮族长寿家系子女ACAT1 rs1044925基因多态性与血脂水平的相关性
Association between ACAT-1 rs1044925 polymorphism and serum lipid levels of longevity's offspring in Guangxi Hongshuihe river basin
摘要
Abstract
Objective To investigate the relationship between the rs1044925 polymorphism on Acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) gene and serum lipid levels of longevity's offspring in Guangxi Hongshuihe river basin.Methods Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) and DNA sequencing were used to examine the genotype of rs1044925 locus on ACAT-1 gene for 473 longevity's first offspring (aged 51-72) and 311 second offspring (aged 31-50),346 and 243 ethnicity matched healthy controls (aged 51-72 and 31-50) residing in Hongshuihe river basin,northwest Guangxi Province.Association analysis were then undertaken between rs1044925 genotypes and serum levels including total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL) and low density lipoprotein (LDL).Results There was no significant difference in genotypic and allelic frequencies of rs1044925 forlongevity's offspring and controls (P ＞ 0.05).All longevity's offspring had the higher systolic blood pressure and TG level (P ＜ 0.05),then systolic blood pressure,TC,TG,LDL levels were higher in longevity's first offspring and only LDL level was higher in the second longevity's offpring,compared with controls (P ＜ 0.05) ; in longevity's first offspring and the second offspring,allele C carriers had a higher TG level than non-C carriers (P ＜ 0.05).In controls,allele C carriers had a higher HDL level than non-C carriers (P ＜ 0.05).Conclusions There was no direct correlation between ACAT-1rs1044925 polymorphism and longevity in longevity's offspring in Guangxi Hongshuihe river basin,but it may affect lipid levels to influence the human life.关键词
胆固醇酰基转移酶1/血脂/长寿家系/单核苷酸多态性Key words
cholesterol acyltransferase-1/blood lipid/ longevity families/ single nucleotide polymorphism分类
医药卫生引用本文复制引用
宋臻,吕泽平,罗桓,潘尚领,胡才友,杨铭,杜丽丽,彭均华,罗晓秋..广西红水河流域壮族长寿家系子女ACAT1 rs1044925基因多态性与血脂水平的相关性[J].山东医药,2013,53(20):18-21,4.基金项目
国家自然科学基金资助项目(30860126,31160209) （30860126,31160209）
广西自然科学基金资助项目(2010GXNSFA013153). （2010GXNSFA013153）
