山东医药2013，Vol.53Issue(21)：17-19,3.DOI:10.3969/j.issn.1002-266X.2013.21.006
脑动脉瘤壁和脑胶质瘤组织中TGF-β1及VEGF的表达及意义
Expression and significance of VEGF and TGF-β1 in cerebral aneurysm walls and brain glioma tissues
摘要
Abstract
Objectives To investigate the expression and significance of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) in cerebral aneurysm walls and brain glioma tissues.Methods Specimen A (15 cases) was excised by craniotomy from a cerebral aneurysm which was diagnosed by CTA; specimen B (15 cases) was from a MRI diagnosed glioma; specimen C (2 cases) was the control group,normal cerebral artery tissue,which was harvested in a trauma case.The expression of VEGF and TGF-β1 in cerebral aneurys.m walls and brain glioma tissues was detected by the immunohistochemical technique.Results The pasitive expression of VEGF and TGF-β1 in either specimen A or specimen B were higher than the specimen C (control group) (all P ＜ 0.05).Conclusions The pasitive expression of TGF-β1 and VEGF was high in cerebral aneurysm walls and brain glioma tissues,and no expression in normal cerebral artery tissue.The VEGF and TGF-β1 may play a role in the vascular wall damage and they are associated with the formation of cerebral aneurysms and brain glioma.关键词
颅内动脉瘤/神经胶质瘤/内皮生长因子/转化生长因子-β/免疫组织化学Key words
intracranial aneurysm/ gliosarcoma/ endothelial growth factor/ transforming growth factor beta/ immunohistochemistry分类
医药卫生引用本文复制引用
杨松,唐万忠,聂安国..脑动脉瘤壁和脑胶质瘤组织中TGF-β1及VEGF的表达及意义[J].山东医药,2013,53(21):17-19,3.基金项目
山东省自然科学基金资助项目(Y2006C13). （Y2006C13）
